Fig. 8 | Nature Communications

Fig. 8

From: Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex

Fig. 8

Model of dysregulated epigenetic events throughout the diurnal cycle in PWS. The PWS locus becomes condensed during light hours (ZT0–ZT12). Epigenetic regulators are expressed at aberrantly high levels at ZT6 and DNA methylation nadirs are lost at ZT6 (including at the TS locus). The TS locus undergoes delayed decondensation (ZT12–ZT16), potentially to compensate for PWS locus compaction. By ZT16, PWS decondensation is restored and DNA methylation nadirs are gained, representing a diurnal shift in rhythmic methylation and a light-specific dysregulation of chromatin decondensation. Red text indicates changes observed in Snord116+/−. Open circles indicate unmethylated CpGs

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