Fig. 5
From: Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation
Keratinocyte-derived IL-23p19 is important for skin inflammation in N-WASP knockout. a Strategy of loxP insertion in mouse IL-23A gene. b, c CD45, K6, Ki67 immunofluorescence of back skin section from 6-week-old con, ko, and dko (b), quantification of mean fluorescence intensity of CD45, and quantification of Ki67-positive cells in interfollicular epidermis (IFE) (n: 5/5/5, mean ± SD, one-way ANOVA, with Tukey’s multiple comparisons). Scale bar: 100 µm. d qRT-PCR analysis of indicated genes from back skin RNA 6–8-week-old of con, ko, and dko mice. All normalized to GAPDH (n > = 6/6/6, mean ± SD, one-way ANOVA, with Tukey’s multiple comparisons; *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001; ****p ≤ 0.0001)
