Fig. 8
Neoantigen-independent CTL infiltration correlates with increased ATM across cancer lineages. a Spearman correlation coefficient between CTL score and total ATM determined by RPPA (blue bars), as well as between CTL score and neoantigen levels (red bars). Individual plots shown in Supplementary Fig. 8A. P-values determined from Spearman correlation coefficient and adjusted by Holm-Sidak method. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 1 × 10-4. b Correlation coefficient of total ATM protein and CTL levels. Cancers that had significant positive correlation with neoantigen levels showed a lower ATM/CTL correlation than those that did not (Non-neoant. Corr). P-value determined by Wilcoxon rank-sum test. Lines represent median and interquartile range. c Determination of correlation coefficients in M-class and C-class subsets. Correlation coefficients between CTLs and neoantigen load or ATM protein level were assessed for the bulk population (All), as well as M-class and C-class subsets. See Supplementary Fig. 9
