Fig. 7
From: Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs
A schematic model indicating that Srf destabilizes cell identity by repressing cell-type-specific genes. a A model of Srf-related pathways to repress cell-type-specific gene expressions. Srf preferentially binds to open regions which preferentially contain cell-type-specific genes. Various signals, such as Actb expression changes and β-actin polymerization dynamics, are transduced to Srf. Srf activated by Mkl1 inactivates the surrounding regions, possibly by recruiting or activating HDACs. Other signals that regulate Srf through β-actin-independent pathways could also participate in this regulation. b A schematic view of a possible mechanism by which misactivation of Srf causes diseases. When the activity of Srf is at physiological levels, cell-type-specific genes are normally expressed. On the other hand, when Srf is activated at non-physiological levels (misactivation), these genes are repressed, triggering malfunction of the cells and tissues and sometimes leading to disease
