Fig. 2

CD11c^hi B cells are present in nephritic kidney in SLE. Nephritic kidneys from SLE patients were examined for the presence of CD11c^hi B cells. A total of 11 kidney biopsies were examined, of which 6 contained B cell infiltrate as defined in methods where all 6 showed presence of CD20⁺CD11c⁺ double positive B cells. Green shows CD20, red shows CD11c, and yellow indicates double positive cells. a Kidney section of lupus nephritis Class II. b Kidney section of lupus nephritis Class IV-b. Space bars show length as indicated. Scale bars = 1, 20 μM; 2, 3 μM; 3, 50 μM; 4, 10 μM. c Frequencies of CD20⁺CD11c⁺ double positive B cells present in nephritic kidneys as indicated compared to CD20⁺ B cells from six unique lupus nephritis donors