Fig. 3
Comparison of global expression changes between fetal and adult brown adipogenesis. a Hexbin plot of global gene expression changes for 14 487 mRNAs (top panel) and 586 lncRNAs (bottom panel) with detectable expressions during both fetal and adult BAT adipogenesis. Density of the data points is represented by color scales. PC primary cells, CL cell lines. b Venn diagram comparing fetal and adult BAT’s transcripts that are regulated (1.5-fold) during adipogenesis. mRNAs (top) and lncRNAs (bottom). c Heatmap depicting 93 lncRNA–mRNA pairs having at least 1.5-fold change between pre-adipocytes and mature adipocytes for both primary cells and cell lines. Pairs are grouped by the lncRNA–mRNA correlation status. Blue and magenta bars represent the lncRNA–mRNA pairs with coherent down- and upregulations during brown adipogenesis. Yellow bar represents the pairs for which the lncRNAs show anti-correlation with mRNA while gray bar represents the pairs, which show incoherent correlation. d Top 10 enriched gene ontology processes of the mRNAs in the upregulated lncRNA–mRNA pairs during both fetal and adult BAT adipogenesis (magenta category from c)
