Fig. 4

Combination CP1 and anti-PD-1 immunotherapy is efficacious in treating orthotopic prostate tumors. a Kaplan–Meier survival curve of Unt., CP1, anti-PD-1 antibody, or combination CP1 and anti-PD-1 antibody treated mice, mice n = 6–12/group, performed in three independent experiments. b Waterfall plot of IVIS imaging quantification, with each bar representing the post-treatment (Tx) total flux of a single tumor normalized to both its own pre-tx total flux and Unt. normalized total flux, with representative images. Percentages indicate the fraction of tumors with values <0.0001; n = 11–17 mice/experimental group, performed in four independent experiments. Post-tx tumor c volumes, d weights, and e gross images, mice n = 3–4/group. Data represented as mean ± S.E.M. Statistical significance was determined by a Log-rank test, c, d two-tailed Student’s t-test. **P < 0.01