Fig. 3
From: In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy
Cellular localization of N-PCNSs in HepG2 and its effects on viability. a Effect of N-PCNSs on HepG2 cell viability (n = 6). Insert: H2O2 cytotoxic effects on HepG2. b Determination of cell membrane integrity by LDH assay. Statistical significance is assessed by unpaired Student’s two-sided t-test compared to the control group. ***p < 0.001. Mean values and error bars are defined as mean and s.d. (n = 4). c Influence of N-PCNSs treatment on mitochondrial membrane potential. Scale bar: 100 µm. d ROS level in HegG2 cells after N-PCNSs-3 stimulation. Scale bar: 20 µm. e Gene ontology analysis of biological process after N-PCNSs treatment. The changes of mRNA in responses to the hypoxia and organic cyclic compound were marked in the figure as Hypoxia and Organic cyclic compound, respectively. p values are assessed by Fisher’s exact test. f Localization of N-PCNSs in HepG2 cells. Scale bar: 10 µm. The Pearson’s coefficient of N-PCNSs and lysosome is 0.8214
