Fig. 7 | Nature Communications

Fig. 7

From: TERRA recruitment of polycomb to telomeres is essential for histone trymethylation marks at telomeric heterochromatin

Fig. 7

Model of TERRAs as a master regulator of the heterochromatic status of the telomere. Diagram showing how TERRA recruits the PRC2 complex (EED, EZH2, SUZ12) and directs it to the telomere. Upon binding of PRC2 to the telomere, PRC2 catalyzes H3K27 methylation. This mark facilitates then the deposition of H3K9m3 and H4K20m3 and the recruitment and stabilization of HP1 protein at the telomere, important to maintain the heterochromatic status of the telomere. In the 20q-TERRA KO cells PRC2 is not recruited to the telomere, and the heterochomatic marks and HP1 protein are not taking place

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