Fig. 2 | Nature Communications

Fig. 2

From: A geometric approach to characterize the functional identity of single cells

Fig. 2

Workflow of ACTION cell-to-cell similarity metric. Computation of the ACTION metric consists of three main steps. i The effect of universally expressed genes is masked out to construct an adjusted transcriptional profile. ii A gene expression specificity vector is computed that assigns weights to each gene based on its informativeness. iii The ACTION kernel is computed as the weighted dot product of adjusted transcriptional vectors

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