Fig. 7
From: LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus
BL001 potentiates islet genes involved in immunomodulation. Isolated mouse islets were treated with 0.1–10 μM BL001 for 24 h and RNA isolated for DNA microarray analysis (n = 3 independent islet preparations per BL001 concentrations). a Venn diagram depicting the number of GO terms significantly enriched after three different BL001 treatment. b Enrichment plot for the seven GO terms common to all three BL001 concentrations. c Heatmaps displaying logFC values of transcripts modulated by BL001, and their association with common GO processes. Blue cells reflect the membership of a gene to a given GO BP term. Validation by QT-PCR of d Ccl2, e Ptgs2, f Ccl3, g Il1r1, h Ccl7, and i Il6 transcript levels in mouse islets treated with BL001. n = 5 independent islet preparations. *p < 0.05 and **p < 0.01, Student’s t test versus control untreated (C)
