Fig. 8 | Nature Communications

Fig. 8

From: Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling

Fig. 8

Model of our inducible axonemal deglutamylation system, STRIP, and proposed roles for tubulin glutamylation. The proximal end of the axoneme is subjected to polyglutamylation. Axonemal glutamylation facilitates kinesin-2-mediated anterograde IFT and the ciliary entry of the Hedgehog pathway components Smoothened (Smo) and Gli3 upon Hedgehog stimulation. The translocation of the CCP5 catalytic domain (CCP5CD) onto the MAP4m-appended axoneme by adding rapamycin specifically strips axonemal glutamylation and subsequently inhibits anterograde IFT and Hedgehog signaling without noticeably affecting the ciliary structure in the steady state

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