Table 1 Parameter estimates from dose-response model fitting to experimental data

Parameter	p	\({\mathbf{\alpha}} _{{\bf Wolb}^{\bf +}}\)	\({\mathbf{\theta}} _{{\bf Wolb}^{\bf +}}\)
Brazil
MAP	1.149 × 10⁻⁷	0.3332	20.77
Median	1.066 × 10⁻⁷	0.3465	26.54
95% CI	5.720 × 10⁻⁸	0.1547	2.566
95% CI	1.837 × 10⁻⁷	0.8907	447.0

Parameter	\({\mathbf{\alpha}} _{{\bf Wolb}^{\bf -}}\)	\({\mathbf{\theta}} _{{\bf Wolb}^{\bf -}}\)	\({\mathbf{\alpha}} _{{\bf Wolb}^{\bf +}}\)	\({\mathbf{\theta}} _{{\bf Wolb}^{\bf +}}\)
Vietnam
MAP	0.3602	347.1	0.2047	910.3
Median	0.3652	401.9	0.2064	944.5
95% CI	0.3045	235.4	0.1677	437.7
95% CI	0.4366	761.4	0.2522	2363

MAP denotes maximum a posteriori probability. In Brazil, p is the probability of infection for a Wolb⁻ mosquito per unit of viral challenge (TCID₅₀), and \({\rm \alpha}_{{\rm Wolb}^+}\), \(\theta_{{\rm Wolb}^+}\) are the shape and scale parameters, respectively, of the gamma distribution determining the susceptibility factors of Wolb⁺ mosquitoes in relation to Wolb⁻ (i.e., with respect to p). In Vietnam p_aux = 10⁻⁸ (per log₁₀ viral titre (RNA copies/ml)), was used as an auxiliary parameter, while \({\rm \alpha}_{{\rm Wolb}^–}\), \(\theta _{{\rm Wolb^-}}\) and \({\rm \alpha}_{{\rm Wolb}^+}\), \(\theta _{{\rm Wolb^+}}\) define the distributions of susceptibility of Wolb⁻ and Wolb⁺ mosquitoes, respectively, in relation to p_aux

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