Fig. 6
The association between LINC01138 and PRMT5 is a candidate therapeutic target for HCC. a RNA pull-down assays for the specific association of PRMT5 and LINC01138, in the cells exposed to PRMT5 inhibitors at the indicated concentration for 48 h. b SMMC-7721 cells were transfected with plasmids containing HA-tagged PRMT5, and RIP assays were performed using HA antibodies in the cells treated with PRMT5 inhibitors at the indicated concentration for 48 h. c CCK-8 assays for pWPXL-LINC01138 or vector cells, exposed to PRMT5 inhibitors at the indicated concentration for 3 days. d CCK-8 assays in cells transfected with si-NC or si-LINC01138 mixture, exposed to PRMT5 inhibitors at the indicated concentration for 3 days. e IC50 were analysed in cells transfected with si-NC or si-LINC01138 mixture, exposed to PRMT5 inhibitors for 3 days. Values are expressed as the mean ± SEM, n = 3 b–e. **P < 0.01 and ***P < 0.001
