Fig. 2
From: Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma
Adipophilin and mismatch repair protein expression distinguish subtypes of sebaceous carcinoma. UV tumors tend to be more poorly differentiated (a), but adipophilin staining confirms sebocytic differentiation (d). MSI tumors tended to be well-differentiated with clear sebocytic differentiation easily identifiable on routine hematoxylin/eosin staining (b,e). This MSI tumor had loss of MSH-2 expression detectable by immunostaining (h,k). Pauci-mutational SeC can manifest both moderately differentiatiated (c,f) and well differentiated phenotypes (not shown). Both MSH-2 and MLH-1 expression is preserved in UV (g,j) and pauci-mutational SeC (i,l). Scale bar 0.1 mm.
