Fig. 5 | Nature Communications

Fig. 5

From: The molecular basis of JAK/STAT inhibition by SOCS1

Fig. 5

SOCS1 does not bind to any pTyr sites on the interferon gamma receptor. a Schematic diagrams of the IFN-α, ɣ and IL-2 receptors. All intracellular tyrosines are shown. b Table showing the binding affinities of human SOCS1 for each IFN-ɣ and IL-2 receptor phosphopeptide. Errors represent standard deviation from three independent experiments. c Representative ITC curves are shown for the four IL-2R phosphopeptides that bind to SOCS1 with sub-micromolar affinity

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