Fig. 5
From: Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration
Overexpression of PA28α improves retinal function in P23H mice. a, b Response amplitudes of ERG a- and b-waves evoked by light flashes of increasing intensity were measured in PA28α overexpressing P23H mice, their control P23H littermates, and WT animals at the ages of 3 (a) and 6 (b) months. The number of eyes analyzed at 3 months was: P23H—6, P23H/PA28α OE—6, WT—3; the number of mice analyzed at 6 months was: P23H—3, P23H/PA28α OE—4, WT—4. Data were averaged and fitted using a single (for the a-wave) or double (for the b-wave) hyperbolic function. Error bars represent SEM. On the right are shown representative ERG recordings from animals of each genotype evoked by flashes of three indicated intensities representing scotopic, mesopic, and photopic light intensity ranges
