Fig. 8 | Nature Communications

Fig. 8

From: Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function

Fig. 8The alternative text for this image may have been generated using AI.

A schematic model on the role of Nsd2-mediated H3K36me2 in adipose tissue development and function. In progenitor cells, depletion of Nsd2-mediated H3K36me2 by H3.3K36M leads to defects in adipose tissue development (adipogenesis) and muscle development (myogenesis). In mature adipocytes, depletion of H3K36me2 by H3.3K36M reprograms functional gene expression, impairing brown and white adipose tissue functions

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