Fig. 6
From: Theoretical principles of transcription factor traffic on folded chromatin
Highly occupied targets in the human genome. a Hi-C map of the human cell line GM12878, along with the position of the highly occupied targets (HOTs) indicated by black dots. b HOTs are enriched at chromosomal loops in GM12878. The location of the HOTs from Foley and Sidow30 was crossed with the location of the loops from Rao et al.30,31. Out of 12,887 HOTs, 2138 were found in loops versus 528 expected (binomial distribution P < 10−9). c HOTs are located in uncompacted chromatin. The violin plots show the distribution of contact decay in 50 kb windows in the whole genome versus each HOT. The mean values are −1.22 and −1.37, respectively (95% confidence interval for the difference 0.146–0.157, Student’s t test with Welch–Satterthwaite correction and 18,080 degrees of freedom P < 10−9). The white dot inside each violin represents the median of the distribution. The black block ranges from the first to the third quartile and the whiskers range from the first to the ninth decile
