Fig. 4
From: Defining a conformational ensemble that directs activation of PPARγ
Agonists reduce the conformational complexity of the co-regulator-binding surface. a Fluorine NMR spectra of PPARγC313A,Q322C-BTFA bound to the indicated ligands. The small sharp left-shifted peak in all the spectra is free BTFA. b Trajectory frame from a simulation of PPARγC313A,Q322C-BTFA bound to a coactivator peptide (MED1; green) with 322C-BTFA shown in orange as spheres (fluorine atoms are turquoise). These experiments were performed once
