Fig. 3
From: Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis
The Piezo1 antagonist GsMTx4 reduces the severity of pancreatitis. C57BL/6J mice were either sham-operated (control) or received intrapancreatic duct infusion of buffered saline at 25–33 mm Hg (pressure). GsMTx4 (270 µg/kg) was administered by intraperitoneal injection 1 h prior to intrapancreatic duct infusion of saline at 25–33 mm Hg (pressure + GsMTx4). a Blood amylase, b pancreatic MPO, and c histological scoring of pancreatitis severity were measured. Statistical analysis was performed using ANOVA test with Tukey’s post-test. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001 (n = 6). d Representative images of pancreatic tissue stained with H&E. Bar = 100 µm
