Fig. 1
From: Efficacy of a respiratory syncytial virus vaccine candidate in a maternal immunization model
VLP immunization of naive and RSV-primed female cotton rats. Diagram of the animal protocol. Female cotton rats were primed by i.n. infection with RSV A/Long (105 PFU i.n.) or left unprimed. Eight weeks later, all females were set in breeding pairs with naive males. At week 10 (the time called "before vaccination", B.V.), primed and unprimed females were divided into groups of animals that were mock-immunized, immunized i.m. with different VLPs, F protein preparations, or with live RSV i.m. Pup delivery started on week 12 (time called "before delivery", B.D.). All pups were challenged with RSV at 4 weeks of age, and sacrificed 4 days later
