Fig. 4
From: Efficacy of a respiratory syncytial virus vaccine candidate in a maternal immunization model
Total IgG antibodies specific for RSV pre-F, post-F, and G proteins generated by VLP immunization. Serum samples in each group at each time point during the experiment were pooled. Top row shows total IgG specific for soluble pre-F (a), post-F (b), or G (c) proteins in serum from animals that were unprimed and vaccinated as indicated. Middle row shows total IgG specific for soluble pre-F (d), post- F (e), or G (f) proteins in serum samples from animals that were RSV primed and vaccinated as indicated. Results show the average of 3–5 separate determinations. Arrowheads in mock-vaccinated animals depict the drop in total RSV-specific IgG antibodies measured in serum samples collected before the time of delivery. p-values for week 13 serum antibody levels are shown in Supplementary Fig. 7. Bottom row shows total IgG specific for soluble pre-F (g), or post-F (h) in serum samples from animals that were either RSV unprimed or primed and vaccinated as indicated. Results show the mean ± SD of 3–5 separate ELISA assays using a new pool serum samples from each group
