Fig. 2

Cell autonomous control of B cell proliferation and differentiation. a B220 expression and PE binding of control (C) (CD45.1⁺CD45.2⁺ Dnmt3a^fl/+Dnmt3b^fl/+) and KO (CD45.2⁺ Cd19^cre/+Dnmt3a^fl/flDnmt3b^fl/fl) cells in the inguinal and periaortic lymph nodes (LN) 30 days after PE-CFA challenge. b Fas and GL7 expression on B220⁺PE⁺ LN cells in a. c CD138 and B220 expression on C and KO cells in the spleen (Spl; top) and bone marrow (BM; bottom) of chimeric mice. All data are lymphocyte size gated and CD11b⁻CD11c⁻F4/80⁻Thy1.2⁻. P values are calculated using a paired t-test. Data represent two experiments with four and five mice per experiment with four male and five female mice