Fig. 5 | Nature Communications

Fig. 5

From: Distinct homeostatic modulations stabilize reduced postsynaptic receptivity in response to presynaptic DLK signaling

Fig. 5

hiw mutants fail to express PHP following chronic loss-of-GluRIIA receptors. a Schematic and representative EPSP and mEPSP traces of recordings in wild type, GluRIIA mutants (GluRIIA: w;GluRIIASP16), hiw mutants, and hiw;GluRIIA double mutants (hiwΔN;GluRIIASP16). Quantification of mEPSP (b) and EPSP (c) amplitude in the indicated genotypes shows a reduction in mEPSP amplitude but failure to maintain baseline EPSP levels in hiw;GluRIIA. d Quantification of mEPSP and quantal content values normalized to baseline (without loss-of-GluRIIA) of the same genotype. No homeostatic increase in quantal content is observed in hiw;GluRIIA mutants. Error bars indicate ± SEM. For statistical significance, an unpaired t-test was performed. ***p 0.001; ****p 0.0001; NS not significant, p > 0.05

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