Fig. 6

Mechanism for efficient MACV cross-neutralization. a Ribbon diagram of MACV GP1 (gray) with loop 10 shown in yellow, and CR1-07 CDR H2 and CDR H3 (as determined in the MACV GP1/CR1-07 Fab complex) in red. To allow for comparison of antibody CDR segments, the structures of the JUNV GP1/GD01 Fab complex (PDB: 5EN2),¹⁴ of the JUNV GP1/OD01 complex (PDB: 5NUZ),¹⁵ and of the JUNV GP1/CR1-28 Fab subcomplex were overlaid onto MACV GP1 by aligning the GP1s. JUNV GP1 used for alignment of the complexes is omitted for clarity. b Surface representation of JUNV GP1 (PDB: 5EN2,¹⁴ gray) with GD01-interacting residues shown in purple. c Surface representation of JUNV GP1 (gray) with OD01-interacting residues shown in light blue. d Surface representation of JUNV GP1 (gray) with CR1-28-interacting residues shown in black. e Surface representation of MACV GP1 (gray) with CR1-07-interacting residues shown in red. f Surface representation of MACV GP1 (PDB: 3KAS,¹³ gray) with TfR1-interacting residues shown in dark blue