Fig. 1 | Nature Communications

Fig. 1

From: AID/APOBEC-like cytidine deaminases are ancient innate immune mediators in invertebrates

Fig. 1

Sequence conservation of AID/APOBEC-like deaminases in S. purpuratus. a Amino acid sequence alignments of human AID (HsAID) and the S. purpuratus SpAIDL1 and SpAIDL4a with the pfam08210 APOBEC-like N-terminal domain present in all vertebrate AID/APOBEC polynucleotide deaminases. Absolutely conserved residues including the catalytic HxE-PCxxC motif are shown in red, while conservation limited to HsAID or SpAIDL1/4a and pfam08210 are indicated in green or blue, respectively. b Schematic representation of the open reading frames of SpAIDL1, 2, 3, 4a, and 9 encoded by alleles from three unrelated individuals. Regions where the PCR primers precluded obtaining sequences are marked in dark blue, and the location and nature of polymorphisms are indicated

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