Fig. 4

Integration of intrinsic molecular subtypes and clinical risk stratification. a Kaplan–Meier curves of overall survival following initial hepatic resection of limited de novo CRCLM based on integrated risk classification of molecular subtype and clinical risk scores (CRS). P-value was determined using a log-rank test. b Metastatic recurrence patterns for integrated risk groups. Asterisks denote statistical significance based on Fisher’s exact test for each individual group versus the two additional groups. c Proposed classification of colorectal liver metastasis based on integrated molecular subtypes