Fig. 5
Tf-NPs loaded with JQ1 and TMZ have superior pharmacodynamic effects in intracranial orthotopic models of glioblastoma. Representative bioluminescent images of a U87MG and b GL261 mice taken on day 0 and day 5 following initiation of treatment with free drug formulations (free drug), drugs loaded in PEG-Cy5.5 liposomes (PEG-NP drug), or transferrin-PEG-Cy5.5 liposomes (Tf-NP drug). Quantification of average tumor bioluminescence values in the different treatment arms throughout the course of treatment for c U87MG and d GL261 mice. Kaplan–Meier survival plots of e U87MG and f GL261 glioma mice in the different treatment arms. Study powered with eight mice per treatment arm for statistical significance. Log-rank (Mantel–Cox) test performed on survival plots. Student t-test used to quantify differences in treatment arms (*p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001)
