Fig. 6
U87MG and GL261 mice treated with dual drug-loaded Tf-NPs demonstrate increased DNA damage and apoptosis in tumors. Quantification of number of tumor cells that stained positive for markers of DNA damage (γH2AX), apoptosis (CC3), and proliferation (Ki67) in a U87MG and b GL261 mice that received free drug vs liposome-loaded drug (Tf-NP). Signal intensity was quantified from >300 cells in tumors of three mice per treatment condition using ImageJ. Data presented as mean ± SEM (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)
