Fig. 7 | Nature Communications

Fig. 7

From: Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles

Fig. 7

Immunocompetent GL261 mice treated with drug-loaded Tf-NPs are protected from systemic drug toxicity. Mice treated with drug-loaded Tf-NPs demonstrated relative protection from a leukopenia and b thrombocytopenia caused by JQ1 and TMZ. Mice in either treatment arm did not demonstrate drops in RBC counts (c), which is known to be unaffected by JQ1 or TMZ. d Quantification of average daily body weights of mice at the end of the 96 h treatment course. Study powered with five mice per treatment arm for statistical significance. Student t-test used to quantify changes in hematopoietic profiles between free drug and Tf-NP treatment arms (*p < 0.05; **p ≤ 0.01; ***p ≤ 0.001, ****p ≤ 0.0001)

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