Table 1 Average diameter, polydispersity index, zeta potential, and drug-loading properties of liposomes

From: Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles

Nanoparticle

Zavg dh (nm)

Polydispersity index

Zeta potential (mV)

JQ1 loading (wt%, EE)

TMZ loading (wt%, EE)

JQ1 + TMZ loading (wt%, EE)

PEG

136

0.15

−6.3

N/A

N/A

N/A

Tf-PEG

137

0.17

−12.1

2.1%, 35.1%

2.9%, 48.3%

JQ1: 2.3%, 38.3%

TMZ: 2.7%, 45.1%

Fol-PEG

165

0.11

−13.7

N/A

N/A

N/A

Hg-PEG

160

0.13

+7.6

N/A

N/A

N/A

  1. Average diameters (Zavg dh, nm) and polydispersity indices (PDI) of PEGylated-(PEG) liposomes or liposomes functionalized with transferrin (Tf), folate (Fol), or hemagglutinin (Hg). Drug-loading properites of Tf-NPs containing either JQ1, Temozolomide, or JQ1 + Temozolomide (wt% = % of nanoparticle mass that is drug; EE encapsulation efficiency)
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