Fig. 1 | Nature Communications

Fig. 1

From: Outlier response to anti-PD1 in uveal melanoma reveals germline MBD4 mutations in hypermutated tumors

Fig. 1

Disease course and immune response in patient UVM_IC. a Disease course since diagnosis. b Evolution of the GNAQQ209L mutation in circulating tumor DNA (ctDNA). c Computed tomography images at second relapse (14 months) and after 10 months of pembrolizumab (24 months). Arrows and circles show locations of metastases; asterisks indicate a simple hepatic cyst. d Proportions of blood effector memory CCR7−/CD45RA−/CD4+ and CCR7−/CD45RA+/CD8+ T-cells in 12 metastatic uveal melanoma patients treated with PD-1 inhibitors, including UVM_IC (red line)

Back to article page