Fig. 7
XPF mutations that result in Fanconi anemia or combined Fanconi anemia/Cockayne Syndrome are deficient in 3′ flap removal. a FA causing XPF mutations are located near XPF-E239. Conserved residues are highlighted in blue. Mutations analogous to human mutations that result in Fanconi anemia or Fanconi anemia/Cockayne Syndrome are indicated. Rad1-E349 is indicated by a black dot. b The effect of FA-causing rad1 mutations on single-strand annealing. c Serial dilutions of rad1 mutants analogous to FA-causing XPF mutants after UV (10 J/m2) treatment. d, e Percentage of survival of FA causing XPF mutants after treatment of different doses of HN2 (d) and UV (e)
