Fig. 7
From: Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons
Our working models. a A balanced production of AgRP- and GHRH-neurons is directed at least in part by the Dlx1/2-Otp gene regulatory axis, by which Dlx1/2 suppress Otp expression in developing GHRH-neurons. It remains to be determined if a similar gene regulatory axis that functions to block developing AgRP-neurons from adopting a GHRH-neuronal fate also exists. Also unclear is how Dlx1/2 and Otp control GHRH- and AgRP-neuronal genes, respectively. b Schematic representation of dysregulated production of AgRP- and GHRH-neurons in Dlx1/2cKO and Otp−/− mice relative to control mice
