Table 2 Summary of Receptor-like protein tyrosine phosphatase (PTPR) genes implicated in the regulation of puberty through Japanese and European genome-wide association studies (GWAS) for age at menarche, and pre- and peri-pubertal changes in hypothalamic gene expression
From: Elucidating the genetic architecture of reproductive ageing in the Japanese population
PTPR sub-type | Genesa | GWAS | Expression-up | Expression-down |
|---|---|---|---|---|
I | C | C | ||
IIA | D,F,S | D,F,S | D,S | |
IIB | K,M,U,T | K | M | K,T |
III | B,H,J,O,Q | J | B,J | O |
IV | A,E | |||
V | G,Z1 | G,Z1 | G,Z1 | |
VI | R | |||
VII | N,N2 | N2 | N,N2 |
