Fig. 1 | Nature Communications

Fig. 1

From: FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells

Fig. 1The alternative text for this image may have been generated using AI.

Merkel cells are specified from cells inside the hair placode. a Immunofluorescence analysis of E15 ATOH1-GFP skins shows the localization of ATOH1-GFP(+) early Merkel cells inside hair placodes. Scale = 20 µm. b–d Immunofluorescence staining for the hair follicle stem cell marker SOX9 (red) and early Merkel cell specification marker ATOH1-GFP (green) during early hair follicle morphogenesis at E13.5 (b), E14.5 (c), and E15.5 (d). Basement membrane is labelled by CD104. White arrow indicates Merkel cells. Note that ATOH1-GFP(+) Merkel cells are located inside the hair follicle, adjacent to SOX9(+) cells. e–g Immunofluorescence staining for LHX2 (red) and ATOH1-GFP (green) during early hair follicle morphogenesis at E13.5 (e), E14.5 (f), and E15.5 (g). Basement membrane is labelled by CD104. White arrow indicates Merkel cells. Scale = 50 µm in all panels

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