Fig. 5 | Nature Communications

Fig. 5

From: Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity

Fig. 5

X-ray crystal structure analysis of OP compounds bound to ERα LBD. a–c, Simulated annealing composite omit maps contoured to 1.5 σ for OP-1156 (a), OP-1154 (b), and OP-1074 (c). d–f, Hydrogen bonds formed between OP-1156 (c), OP-1154 (d) and OP-1074 (e) and ERα LBD. Helices 3 and 11 are denoted as H3 and H11 respectively. g–i Enhanced view of OP-1156, OP-1154, and OP-1074 near the H11-12 loop which ultimately perturbs H12 leading to differential activities between the compounds

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