Fig. 2
From: Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width
H3K4me3 width dynamics encode biological information. a Heat map showing Spearman’s rank correlation coefficients among fold changes of H3K4me3 peak heights, areas, and widths under MR in human cancer cells. The upper right part shows density scatter plots comparing the corresponding log2(fold change) values. Colors of dots in the scatter plots indicate density of dots. b Same as in a but for mouse liver. c Distribution of fold changes (defined by the values in low methionine condition divided by the corresponding values in high methionine condition) in peak width. The arrow at the bottom denotes the change from sensitive (more reduction in peak width) to robust (less reduction in peak width). d Number of pathways significantly enriched (GSEA FDR Q-value < 1e-5) in peaks with different dynamics under MR in human cancer cells. e Same as in d but for mouse liver. f Examples of annotated pathways in each category. g Annotation of 298 MSigDB pathways enriched in H3K4me3 peaks with sensitive width in human cancer cells. h Representative cancer-related pathways enriched in H3K4me3 peaks with sensitive width in human cancer cells. i Annotation of 48 MSigDB pathways enriched in H3K4me3 peaks with robust width in mouse liver. j Representative liver-specific pathways enriched in H3K4me3 peaks with robust width in mouse liver
