Fig. 9
From: Complete microtubule–kinetochore occupancy favours the segregation of merotelic attachments
Speculative model for the role of complete KT–MT occupancy. a, b Schematic model of the impact of reduced KT–MT occupancy on sister-KTs before (a) and after (b) anaphase onset. KTs are in green, Aurora-B activity gradient in red, and MTs in red-black. Full and dashed “inhibition” signs in red represent the respective strength of Aurora-B activity on KTs. Full and dashed black arrows represent the respective strength of the force applied by MTs on sister-KTs at anaphase. We postulate that before anaphase (a) complete MT occupancy and high inter-KT stretching is not required for SAC satisfaction; moreover, low inter-KT distances are not sufficient to induce Aurora-B-dependent MT detachment. This indicates that Aurora-B must recognize additional features in syntelic KT pairs. After anaphase onset (b), complete MT occupancy favours the segregation of merotelic chromosomes by increasing the likelihood of a high force differential between the “correct” and “incorrect side of the lagging chromosome
