Fig. 1

Solution structure of the C-terminal domain of human RPAP3 a Schematic representation of the human R2TP complex. b Domain architecture of RPAP3 (numbering corresponds to amino-acids of isoform 1). c Conservation of RPAP3 and PIH repertoires across Eukaryotes. Members in which TPR (Pfam: 13414) or Dynein attachment (Pfam: 15867) domains are associated to the canonical RPAP3_C are colored as indicated at the left. Clades or species that have lost flagella or in which cilia are not motile are in gray background. Members that were not found are indicated by x. d Backbone view of the superposition of the best 20 NMR structures of human RPAP3-Cter, with α-helices indicated in violet. e Sequence of RPAP3-Cter, with corresponding α-helices. f Backbone orthogonal views (180 °C) of RPAP3-Cter structure in ribbon representation with corresponding α-helices