Fig. 6
From: CREB controls cortical circuit plasticity and functional recovery after stroke
Quantitative mapping of motor system connections after stroke and with CREB induction. a, c, e Each map represents all of the digitally mapped connections from all the animals in each condition (n = 4 for each condition) from M1 anterior to the stroke site, collapsed onto a representative tangential section through the mouse cortical hemisphere. The Y and X axes show mm distance from the center of the tracer injection site. The dark blobs on the maps are the location of the primary somatosensory vibrissal field (the “barrel” field). Light blue label corresponds to the condition in the light blue labeled text at the top of each panel; red corresponds to the condition in the red label at the top of each panel; and dark blue is dense overlap. b, d, f In polar plots of connections of forelimb motor cortex projections the plot is made relative to the tracer injection in forelimb motor cortex as the origin. Each filled polygon (blue and red) is the 70th percentile of the distances of all BDA-labeled connections from the injection site in each segment of the graph. The lines in these plots are the median vector of that segment of the plot, multiplied by the median of the normal distribution of the number of points in a given segment of the graph. P value is Hotelling's T2. g Schematic summary of axonal sprouting after stroke with CREB induction
