Fig. 5
From: Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver
Profibrogenic properties of MAIT cells in vivo. Representative images and quantification of Sirius red and α-SMA areas, and hepatic TGF-β1 secretion in a MAIT cell-deficient (MR1−/−) mice (n = 5) and their WT littermates (n = 6) chronically administered with CCl4, b MAIT cell-enriched (Vα19TCRTg) mice (n = 9) and their WT littermates (n = 10) chronically exposed to CCl4 in two independent experiments (exp 1, n = 5 WT, n = 4 Tg; exp 2, n = 5 WT, n = 5 Tg), and c MAIT cell-enriched (Vα19TCRTg) mice (n = 9) and their WT littermates (n = 3) subjected to bile duct ligation. Scale bar = 100 μm. Statistical analysis was performed using Mann–Whitney (a, b, c). *p ≤ 0.05 vs. WT
