Fig. 2 | Nature Communications

Fig. 2

From: Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies

Fig. 2

Clonal evolution of CRC cell populations upon secondary resistance to targeted agents. Phylogenetic evolutionary maps illustrate the development of sub clonal populations after acquisition of secondary resistance to the targeted therapies. The bioinformatic tool EXPANDS was used to infer the clonal architectures using gene copy number, synonymous and non-synonymous somatic mutations, as described in detail in the Material and Methods section. Each circle represents a subclonal population, numbers indicate non-synonymous variations defining clonal sweeps. Length of the branches is proportional to the number of variants (synonymous and non-synonymous) acquired by individual clones, while ancestral branches define the main colour of its subclones. Subpopulations carrying somatic alterations known to drive drug resistance are highlighted (see Supplementary Table 1). The dashed line indicates KRAS amplification

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