Fig. 1
From: In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer
In vivo functional screening for KRAS effectors driving metastasis. a Illustration of Oncogenomics informed screening of DNA barcoded candidate genes cloned by HiTMMoB and introduced into non-metastatic 393 P murine tumor cell line via lentiviral transduction. b Individual ORF-barcoded cell lines were pooled and injected into the flanks of immunocompetent 129 Sv mice, followed by barcode enrichment analysis of injected cells (Input), subcutaneous (SQ) tumors and lung metastases (see text for details). Representative histogram illustrates positive enrichment of hypothetical driver of SQ growth (BC2) and lung metastasis (BC4). attB recombination cassettes; BC barcode. Elements of image used with permission of Patrick J. Lynch and Carl Jaffe, MD under Creative Commons Attribution 2.5 License 2006
