Table 1 Association between MTHFD2 network gene loci and plasma metabolites directly or indirectly associated with glycine metabolism
Gene | Metabolite | SNP | p value |
|---|---|---|---|
MTHFD2 | N-acetylglycine | rs10174907 | 1.43E-05 |
EPAS1 | N-acetylglycine | rs1530628, rs2197698, rs1530627 | 8.69E-05, 9.45E-05, 9.76E-05 |
GLDC | Glycine | rs2297442 | 2.94E-05 |
AARS | Tyrosine | rs9936903 | 1.89E-08 |
LTA4H | Methionine | rs12579455 | 4.99E-05 |
SETX | Citrulline | rs612169, rs545971, rs674302, rs514659 | 5.91E-05, 6.35E-05, 6.39E-05, 6.86E-05 |
EPAS1 | Tryptophane | rs1530628 | 8.13E-05 |
PCK2 | Glycerol 3-phosphate | rs1062230 | 2.60E-05 |
