Fig. 1 | Nature Communications

Fig. 1

From: Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells

Fig. 1

Small molecules described or anticipated to target key proteins of NHEJ and HDR. Proteins are labeled with black text and inhibitors and enhancing small molecules are marked red and green, respectively. STL127705, NU7026, or SCR7 have been described to inhibit Ku70/80, DNA-PK, or DNA ligase IV, respectively. MLN4924, RS-1, Trichostatin A, or Resveratrol have been described to enhance CtIP, RAD51, or ATM, respectively. NSC 15520 has been described to block the association of RPA to p53 and RAD9. AICAR is an inhibitor of RAD52 and B02 is an ihibitor of RAD51. For simplicity, some proteins and protein interactions are not depicted

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