Fig. 3 | Nature Communications

Fig. 3

From: A quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes

Fig. 3The alternative text for this image may have been generated using AI.

Application of qPLEX-RIME in CREBBP, NCOA3 and POLR2A. a Peptide sequence coverage of the CREBBP (CBP) protein in the qPLEX-RIME analysis (top panel). The volcano plot summarises the quantitative results of the CBP qPLEX-RIME and several of its known interactors are highlighted in red font (bottom panel). b Peptide sequence coverage of the NCOA3 protein in the qPLEX-RIME analysis (top panel). The volcano plot summarises the quantitative results of the NCOA3 qPLEX-RIME and several of its known interactors are highlighted in red font (bottom panel). c Peptide sequence coverage of the phospho-polymerase II (POLR2A) protein in the qPLEX-RIME analysis (top panel). The volcano plot summarises the quantitative results of the POLR2A qPLEX-RIME and several of its known interactors are highlighted in red font (bottom panel)

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