Fig. 3
From: A recurrent point mutation in PRKCA is a hallmark of chordoid gliomas
Effect on cell proliferation. a PRKCAD463H mutation enhances proliferation of human astrocytes. Human immortalized astrocytes overexpressing PKCαD463H-Myc grow significantly faster (p < 0.0001; ANOVA) than astrocytes overexpressing PKCαWT-Myc, PKCαT638A-Myc, or GFP. This analysis was performed from duplicate plates. b Primary rat tanycytes transduced with PRKCAD463H have a higher DNA replication rate than those transduced with PRKCAWT. Myc-positive cells, and Myc-positive–EdU-positive cells were counted. Results are from three independent experiments. The boxplots indicate the median with the box bounded by the 25 and the 75 percentiles
