Fig. 1
From: Network biology discovers pathogen contact points in host protein-protein interactomes
Hubs and bottlenecks are enriched in conditional phenotypes. a Schematic representation of high degree (hub; red), high betweenness (bottleneck; blue), and high eigenvector (green) nodes in a hypothetical network. b Cataloging loss-of-function mutant phenotypes in Arabidopsis based on five phenotypic groups: essential (ESN), morphological (MRP), cellular-biochemical (CLB), conditional (CND), and no phenotypes (NPH). c, d Node distribution corresponding to degree (c) and betweenness (d) for five phenotypic groups. CND phenotype enrichment for hub and betweenness are shown. e Relationship between node betweenness and degree distribution to identify high degree/high betweenness (HDHB), high degree/low betweenness (HDLB), low degree/high betweenness (LDHB) as well as low degree/low betweenness (LDLB) nodes (correlation coefficient of r2 = 0.87). f Hypergeometric test to determine the overrepresentation of a particular phenotypic group in nodes belonging to HDHB (P = 0.03), HDLB (P > 0.05), LDHB (P > 0.05), and LDLB (P > 0.05) categories
